PrincipleChargaff's RulesDNA from any cell of all organisms should have a 1:1 ratio (base Pair Rule) of pyrimidine and purine bases; specifically, the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine.
PrincipleChemiosmotic TheoryThe movement of ions across a semipermeable membrane, down their electrochemical gradient, generates ATP.
PrincipleMichaelis–Menten KineticsDescribes the rate of enzymatic reactions, relating reaction rate to substrate concentration.
PrincipleAnfinsen's DogmaThe native structure of a small globular protein is determined only by the protein's amino acid sequence.
PrincipleLevinthal's ParadoxIt would take an astronomical amount of time for a protein to find its folded state by a random search, implying a directed folding pathway.